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This volume represents the efforts of the many chemists whose ability to master bothsynthetic and medicinal chemistry enabled them to discover a new drug. Medicinal chemistry, like synthetic chemistry, comprises both art and science. It requires a comprehensive mind to collect and synthesize mountains of data, chemical and biological. It requires the instinct to select the right direction to pursue, and the intellect to plan and execute the strategy that leads to the desired compound. Most of all, it requires a balance of creativity and perseverance in the face of overwhelming odds to reach the goal that very few achieve—a successfully marketed drug





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